学科专业：

卫生检验

研究方向：

1.卫生检测技术研究； 2.环境有害因素对健康影响研究

讲授课程：

本科：首批国家一流本科课程（线下）《卫生化学》课程负责人

硕博：《卫生检测技术与应用》、《环境检测技术与应用》、《卫生检测研究进展》

科研项目：

作为项目负责人，主持的重点科研项目：

1.国家十一五“重大新药创制”科技重大专项：《新型稀土杂多化合物抗乙型肝炎病毒的候选药物研究》,   2009ZX09103-105

2.国家自然科学基金面上项目：《基于免疫磁分离和电感耦合等离子体质谱联用技术的三种食源性致病菌同步快速检测技术研究》,81872668

3.国家自然科学基金面上项目：《三种人畜共患传染性病原菌同步快速富集与检测技术研究》，81473018

4.国家自然科学基金面上项目：《多酸基纳米荧光生物探针的制备及其在人畜共患传染病免疫检测中的应用》,81072337

5. 国家自然科学基金面上项目：《基于DNA步行器和CRISPR/Cas12a系统信号级联放大策略的细菌性人畜共患病病原体双通道检测新方法研究》,82273686

6.环境保护部联合国家卫生计生委“全国重点地区环境与健康专项调查项目”—《吉林市中石油吉林石化公司周边地区环境与健康调查》

7.吉林省科技攻关重点项目：《食源性致病菌快速检测技术研究》,   20170204003SF

8.吉林省科技厅重点攻关项目：《多糖合剂保健品的开发与应用研究》, YYZX201123-2

9． 吉林省世行贷款农产品质量安全项目：《食品接触材料的风险分析与安全性控制技术研究》

10.地方政府委托项目《长白山天然矿泉水微量元素健康效应评价》

11.吉林省发改委重点项目《稀土杂多化合物抗病毒药物的开发与应用研究》

12.吉林省发改委项目：《基于MD-LAMP的复合材质自吸式多重食源性病原菌微流控检测芯片开发》

学术论文：

近年来，以通讯作者发表的中科院一区论文：

1. Yuanyuan Guo, Yan Zheng, Yajuan Liu, Xiaopeng Feng, Qinghai Dong, Juan Li*; Juan Wang*; Chao Zhao*; A concise detection strategy of Staphylococcus aureus using N-Succinyl-Chitosan-dopped bacteria-imprinted composite film and AIE fluorescence sensor, Journal of Hazardous Materials, 2022, 423: 126934.

2. Shuo Yao#, Bo Pang#, Yanli Fu, Xiuling Song; Kun Xu, Juan Li*, Juan Wang*, Chao Zhao*. Multiplex detection of foodborne pathogens using inductively coupled plasma mass spectrometry, magnetic separation and metal nanoclusters-mediated signal amplification, Sensors and Actuators: B. Chemical, 2022, 359: 131581.

3. Hang Li, Xuechen Wang, Shengnan Wei, Chao Zhao, Xiuling Song, Kun Xu, Juan Li*, Bo Pang*, Juan Wang*. Applications of hybridization chain reaction optical detection incorporating nanomaterials: A review. Analytica Chimica Acta, 2022, 1190, 338930.

4. Wei Shengnan, Su Zhenyue, Bu Xiangong, Shi Xuening, Pang Bo, Zhang Liang, Li Juan*, Zhao Chao*. On-site colorimetric detection of Salmonella typhimurium. NPJ Sci Food., 2022,6(1):48.

5. Yuan Wei, Jinhui Zhou, Feng Zhao, Chen Chen, Jun Wang, Yufei Luo, Chenfeng Li, Jiahui Xiong, Yuebin Lv, Juan Li*, Xiaoming Shi*. Association of blood lead exposure with frailty and its components among the Chinese oldest old. Ecotoxicol Environ Saf. 2022, 242:113959.

6. Shuo Yao, Chao Zhao, Mingyu Shang*, Juan Li*, Juan Wang*. Enzyme-free and label-free detection of Staphylococcus aureus based on target-inhibited fluorescence signal recovery. Food and Chemical Toxicology, 2021,150, 112071.

7. Huiwen Zhang^#, Yushen Liu^#, Shuo Yao, Mingyu Shang, Chao Zhao, Juan Li*, Juan Wang*. A multicolor sensing system for simultaneous detection of four foodborne pathogenic bacteria based on Fe3O4/MnO2 nanocomposites and the etching of gold nanorods. Food and Chemical Toxicology, 2021,149, 112035.

8. Huiwen Zhang, Shuo Yao, Xiuling Song, Kun Xu, Juan Wang, Juan Li*, Chao Zhao*, Minghua Jin*. One-step colorimetric detection of Staphylococcus aureus based on target-induced shielding against the peroxidase mimicking activity of aptamer-functionalized gold-coated iron oxide nanocomposites. Talanta, 2021, 232:122448.

9. Yuan Wei, Yuebin Lv, Jinhui Zhou, Xiang Gao, Jun Duan, Chao Zhao, Zhaoxue Yin, Qi Kang, Bing Wu, Chen Chen, Chen Mao, Juan Li*, Xiaoming Shi*. Smoking cessation in late life is associated with increased risk of all-cause mortality amongst oldest old people: a community-based prospective cohort study. Age And Ageing, 2021, 50(4):1298-1305.

10. Rui Zhang, Zhiyan Zhu, Hongying Lv, Futian Li, Shuqing Sun*, Juan Li*, Chun-Sing Lee*. Immune Checkpoint Blockade Mediated by a Small-Molecule Nanoinhibitor Targeting the PD-1/PD-L1 Pathway Synergizes with Photodynamic Therapy to Elicit Antitumor Immunity and Antimetastatic Effects on Breast Cancer. Small. 2019,15(49): e1903881.

11. Rui Zhang, Yan Guan, Zhiyan Zhu, Hongying Lv, Futian Li, Shuqing Sun, Juan Li*. Multifunctional Tetracene/Pentacene Host/Guest Nanorods for Enhanced Upconversion Photodynamic Tumor Therapy. ACS Appl Mater Interfaces. 2019, 11(41):37479-37490.

12. Bo Pang, Kaiyue Fu, Yushen Liu, Xiong Ding, Jiumei Hu, Wenshuai Wu, Kun Xu, Xiuling Song, Juan Wang, Ying Mu*, Chao Zhao*, Juan Li*. Development of a self-priming PDMS/paper hybrid microfluidic chip using mixed-dye-loaded loop-mediated isothermal amplification assay for multiplex foodborne pathogens detection. Analytica Chimica Acta, 2018, 1040:81-89.

13. Hongqian Cao, Yang Yang*, Yanfei Qi, Yue Li, Bingbing Sun, Ying Li, Wei Cui, Juan Li*, Junbai Li*. Intraparticle FRET for Enhanced Efficiency of Two-Photon Activated Photodynamic Therapy. Adv. Healthcare Mater. 2018, 1701357.

14. Yushen Liu#, Chao Zhao#, Kaiyue Fu, Xiuling Song, Kun Xu, Juan Wang*, Juan Li*. Selective turn-on fluorescence detection of Vibrio parahaemolyticus in food based on charge-transfer between CdSe/ZnS quantum dots and gold nanoparticles. Food Control, 2017, 80: 380-387.

15. Bo Pang#, Xiong Ding#, Guoping Wang, Chao Zhao, Yanan Xu, Kaiyue Fu, Jingjing Sun, Xiuling Song, Wenshuai Wu, Yushen Liu, Qi Song, Jiumei Hu, Juan Li*, Ying Mu*. Rapid and Quantitative Detection of Vibrio parahemolyticus by the Mixed-Dye-Based Loop-Mediated Isothermal Amplification Assay on a Self-Priming Compartmentalization Microfluidic Chip[J]. Journal of Agricultural and Food Chemistry, 2017, 65(51): 11312-11319.

获得授权发明专利：

1. 李娟,庞博,赵超,徐坤,王娟,宋秀玲,李金华. 一种细菌检测试剂盒[P]. 吉林省：CN110133262B,2021-08-31. 已授权

2. 李娟,郑雁,王新龙,李金华,赵尧,李婉玲. 一种杂多钒酸盐化合物及其制备方法[P]. 吉林省：CN110256482B,2021-04-06. 已授权

3. 李娟,庞博,赵超,牟颖,徐坤,宋秀玲,王娟. 基于LAMP的自吸式多通道病原菌检测微流控芯片[P]. 吉林省：CN107988046B,2021-02-19. 已授权

4. 李娟,齐燕飞,李涵,巩宏伟,孙佳恒,田蕊,暴昊,宋祥福,陈强,刘国良. 硅钨酸盐及其制备方法和应用[P]. 吉林省：CN106986344B,2019-04-26. 已授权

5. 李娟,李丽,徐坤,宋秀玲,殷德辉,宋丹丹,刘玉申,鞠文,王娟,曲笑锋,赵超,魏佳. 一种布鲁氏菌病特异性融合蛋白抗原的制备及应用[P]. 吉林省：CN105906714B,2019-03-15. 已授权

6. 李娟,任明,叶伶艳,徐坤,齐燕飞,曲笑峰,佟瑶,吕琳. 抗辐射和辅助抗肿瘤药物及应用[P]. 吉林省：CN103599125B,2016-01-20. 已授权

7. 李娟,牛俊奇,齐燕飞,姜艳芳,王娟,张红,李金华,原野,孟凡旭,宋秀玲. 抗肝炎病毒的铌钨酸盐化合物[P]. 吉林省：CN101844811B,2011-12-28. 已授权

8. 李娟,韩正波,王恩波,李静,吴欣雨,孙志伟,王宏芳,徐坤,于洗河. 稀土杂多化合物抗病毒药物[P]. 吉林省：CN100390183C,2008-05-28. 已授权

9. 李娟,李雪静,李静,王宏芳,孙志伟,徐坤,吴新宇,侯雷. 抗辐射损伤药物[P]. 吉林省：CN100360137C,2008-01-09. 已授权

著作教材：

主编、副主编教材：
1.《化妆品检验与安全性评价》，人民卫生出版社，主编

2.《卫生化学》，人民卫生出版社，人民卫生出版社，副主编
3.《公卫医师实践技能应试指导》，协和医科大学出版社，主编
4.《公卫医师应试指导（上、下）》，协和医科大学出版社，主编
5.《现代卫生化学》，人民卫生出版社，副主编
6.《公共卫生学》，厦门大学出版社，副主编

7. 《公共卫生辅助管理员》，中国劳动社会保障出版社，主编

获奖情况：

科研获奖：
1.吉林省自然科学学术成果奖：新型稀土杂多化合物抗病毒的作用研究，一等奖，第一名
2.吉林省科学技术奖：多酸化合物抗病毒作用研究，二等奖，第一名

3.吉林省科学技术奖：长白山锦灯笼有效成分及抗咽炎作用的研究，三等奖，第一名
荣誉称号与获奖：
先后获得国务院特殊津贴、吉林省“长白山学者”特聘教授、吉林省有突出贡献的中青年专业技术人才、长春市优秀人才、长春市师德标兵、吉林省公共卫生与预防医学发展贡献奖、“澳门新葡萄新京app官网医学教育贡献奖”、澳门新葡萄新京app官网白求恩名师、澳门新葡萄新京app官网师德先进个人、澳门新葡萄新京app官网“教书育人”先进个人、优秀共产党员等荣誉称号。